One of the most significant instances was their involvement with John Connally's campaign for Governor of Texas. Connally had already served as the Secretary of the U.S. Navy under President Kennedy. In the early 1960s, he decided to run for Governor in his home state and was elected to office, beginning this role in 1963.
While Granddad was working on the campaign with Connally, Grandmother played a role by supporting Connally's wife (Nellie) with the campaign group "Women for Connally". Here's a newspaper clipping from the Houston Chronicle. I don't have the precise date of this at the moment but will update as soon as I find out.
Maybe in one of our next entries we'll find out how Grandmother got the nickname "Tiger" while involved in yet another campaign - this one, however, somewhat closer to home!